Experienced in analyzing antibody in vitro and in vivo function.
In vitro activity analysis, we have established a series of stable and efficient evaluation methods.
(1)Based on BiacoreTM T200 and OpenSPRTM platforms, we have established a system for evaluating antibody affinity and antibody molecular interactions.
(2) Cellular-level binding and blocking evaluation based on the FACS platform
(3) Evaluation of proliferation promotion and proliferation inhibition at the cellular level based on enzyme assays.
(4) Fc-mediated ADCC/ADCP
(5) PBMC/T cell-based evaluation of antibody activity, MLR.
At present, we have 200+ cell lines and 50+ overexpressed cell lines for functional analysis.
In the in vivo pharmacodynamic analysis, we have established dozens of tumor models for pharmacodynamic evaluation, from in vitro customization to in vivo validation.